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The 2013 Leggett paper used a GHRH-receptor-targeted botulinum-neurotoxin construct to further characterise pulsatile-secretion mechanisms (PMID 23825127)
Most patients benefit from weekly B12 shots initially, then transition to bi-weekly or monthly maintenance based on their response and lab values
they should not be interpreted as established clinical outcomes, and no head-to-head comparative data with other agents currently exist
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