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Histone acetylation HDAC4 (Histone deacetylase-4) a protein with a variety of cellular functions, is downregulated in senescence brought on by oncogenes as well as replication The knockout of this HDAC4 caused senescence in BJ/hTERT/Ras/E1A (BJ-TERT) cells, which are designed to avoid ageing, by upregulating genes linked to senescence and raising SA--galactosidase activity (Wang et al

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Gonzlez-Rodrguez, P

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P., & STEP 1 Study Group

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If IGF-1 levels remain elevated for extended periods, issues with cardiac rhythm and heart valves may develop

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