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A gradual increase in semaglutide dose helps reduce the severity of the side effects

If depleted, you may suffer from fatigue

Patients with metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD) and insulin resistance may experience improvements in hepatic steatosis and liver enzyme elevations, though this represents an off-label use with evolving evidence

Overall, the effects of these compounds on fat metabolism, body mass index, lean mass, and insulin sensitivity might show changes in body weight on long-term treatment, yet they are less likely to offer the same results as GLP-1 patches