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Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens
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These differences probably account for remyelination occurring later in the cortex than in the CC: after acute cuprizone-induced demyelination, OPC repopulation and differentiation is much faster in the CC than in the cortex, resulting in later, incomplete remyelination in the cortex (Gudi et al., 2009
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