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Fourteen days after UUO, the AAV-Ctrl-injected mice presented decreased GPX4 expression and accumulation of lipid hydroperoxide (4-HNE)- and TUNEL-positive cells, as detected by immunofluorescence and TUNEL assays (Sup
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Pigmentation happens because of too much production of melanin in particular areas of the skin resulting in dark patches or an unbalanced colour of the skin
Andersen JM, Sugerman KS, Lockhart JR, Weinberg WA
Also, the mice not receiving vitamin E showed changes in plasma levels of creatinine, urea, and uric acid while these blood parameters did not change significantly in the vitamin E group
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