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I can tell you an example of a patient I saw yesterday that had lost significant weight and they were taking other medications And the dose had to be adjusted significantly because of their weight loss and they didnt know that. Patients on insulin, for instance, might need a lower dose as they shed pounds while using semaglutide

They discovered that semaglutide treatment improved body composition by reducing excess body fat, notably abdominal fat, and increasing the proportion of lean body mass, or weight that is not body fat

Semaglutide, StatPearls Publishing, 2024

Dong B, Ding C, Xiang H, Zheng J, Li X, Xue W