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A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2a Clinical Trial to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetics of Orally Administered TERN-101 Tablets in Adult Patients With Presumed Non-Cirrhotic Non-Alcoholic Steatohepatitis (NASH) (2022)
GSH depletion is known to activate c-Jun N-terminal kinase through redox inhibition of GST, which normally binds to and inhibits stress kinases [170]
This schedule is intentional and reflects how the peptides AMPK pathway activation works
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All animals had access to food and water ad libitum
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