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10.1016/0006-291x(84)91253-1 83 NakamuraT.NishizawaT.HagiyaM.SekiT.ShimonishiM.SugimuraA.et al (1989)

As many as 80-90% of people following a vegan lifestyle may have a deficiency and the reason for this is that vitamin B12 is only found in animal food sources

This established the mechanistic rationale for NNMT inhibition