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Metabolism-dependent neutrophil cytotoxicity of amodiaquine: a comparison with pyronaridine and related antimalarial drugs
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Numerous studies have confirmed that compromised autophagy and mitophagy are associated with ageing, leading to shortened lifespan in a wide range of ageing models, whereas restoration and enhancement of autophagy prolongs life and health in various animal species (Reference Aman, Schmauck-Medina and Hansen24, Reference Zimmermann, Madeo and Diwan26)
Proinflammatory cytokines further stimulate ROS overproduction aggravating ARDS and lung damage causing a vicious circle between oxidative stress and cytokine storm
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