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DPP-4 enzyme cleaves GLP-1 with a half-life of approximately 2 minutes, which is why early drug development focused on DPP-4 inhibitors and on engineering longer-lived GLP-1 analogs
Available from: Accessed 11 Nov 2025 Damholt B, et al
Can I take my dose 12 hours early
The most severe risks include promoting the growth of existing cancers, severe hypoglycemia (low blood sugar), and acromegaly (abnormal bone and organ growth)
That means route of administration can matter for the uptake and effect window of promoting deep sleep or influencing sleep cycles
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