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When administered directly into the cerebrospinal fluid of mice, it showed dose-dependent pain-relieving effects that were blocked by naloxone, confirming involvement of opioid pathways

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(Waldner 2006) A double-blind RCT (n=30) in patients receiving high-dose interleukin-2 therapy reported a reduction in serious cardiac events (e.g., arrhythmias and acute heart failure) with L-carnitine use compared to no therapy, but the small sample size and heterogeneity of the cancer types limit generalizability