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Weight loss in a regular clinical setting was similar to weight loss in randomized clinical trials (30)
The problem is that right now, there are no public agreed upon standards for things like, how do you make this drug, how do you test its quality, and so on and so forth
Ultimately, it destroys the single most important thing in research: reproducibility
Proper injection technique, including rotating sites and using sterile needles, ensures a full dose gets delivered and reduces complications