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Allyl alcohol is rapidly metabolized by alcohol dehydrogenase to acrolein, which damages periportal cells once glutathione levels are depleted
Kim et al., 2015
When Microdosing May Not Be Appropriate Microdosing is not appropriate when core safety or metabolic foundations have not been addressed
Some Phase I reactions produce electrophiles or free radicals that must be rapidly neutralized through glutathione and other Phase II pathways
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