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Patients who are uncomfortable with compounded products can discuss brand-name alternatives with their prescribers, though the brand-name versions do not include glycine or B12 and require separate supplementation to address those concerns

GLP-1 drugs shown cost-effective for knee osteoarthritis and obesity A new study led by investigators at Mass General Brigham finds that adding novel weight loss GLP-1 drugs semaglutide and tirzepatide to usual care represents a cost-effective treatment strategy for people with knee osteoarthritis and obesity, with tirzepatide providing greater health benefits at lower cost compared to semaglutide

Together with John Blundell, we developed the protocol: on two different test days we examined 55 healthy individuals and recorded their appetite sensations before breakfast and every 30 min during the 4.5 hr postprandial period under the same conditions [3]

Semaglutide can reduce appetite, so consistent meals with enough protein help protect lean muscle

Avoiding caffeine, alcohol, and large meals within three hours of bedtime prevents stimulation and digestive discomfort that fragments sleep