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For CME_a, the key residues in the C1 region, N259 and E255, are crucial for its binding, further emphasizing the importance of the C1 region in mTYR (Table 4)

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doi: 10.1016/j.biopha.2018.09.049 94 XinWZhaoXLiuLXuYLiZChenLet al

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Intensive lifestyle changes are necessary to improve insulin sensitivity: a randomized controlled trial