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doi.org/10.1021/acs.jmedchem.5b00726 Deacon, C

Estrogen, Body Composition, and Fat Distribution GLP-1 medications dont directly alter estrogen levels, but weight loss achieved through GLP-1 therapy can have indirect effects on estrogen metabolism that are worth understanding

Their stories, she says, made clear that many people are surprised to find these drugs don't work the same for everyone

The mechanism is likely related to reduced caloric intake and metabolic adjustment rather than a direct drug effect

38 Collectively, these findings highlight semaglutides greater efficacy in weight loss and glycemic control compared to liraglutide across diverse populations and study designs, although tolerability and individual patient characteristics should guide therapeutic choices