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D.DongY.ZieglerK.MarkovicJ.PallardoF
Serotonin Syndrome Counteraction A 2005 study in the European Journal of Pharmacology (PMID: 15840402) induced severe serotonin syndrome using pargyline (MAO inhibitor) plus L-tryptophan (serotonin precursor), producing forepaw treading, hindlimb abduction, wet dog shake, and hyperthermia mediated primarily through 5-HT2A receptors
Because both components share one reconstitution date in a co-formulated vial, the shorter of the two in-use windows governs the whole preparation rather than each component being managed independently
Thorton MJ
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