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Continued exploration and understanding of peptides will be essential in developing effective treatments and improving the quality of life for those affected by chronic diseases
The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased
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Unlike full-length hGH, AOD 9604 does not stimulate insulin-like growth factor 1 (IGF-1) production, thereby avoiding potential adverse effects on glucose metabolism
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