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Ruberti, 00185 Rome, Italy 2 Experimental Neuroscience and Neurological Disease Models, Santa Lucia Foundation IRCCS, 00143 Rome, Italy These authors contributed equally to this work

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Symptoms typically worsen 1-3 hours after eating large meals or when lying flat within 3 hours of eating, as stomach acid more easily refluxes into the esophagus in these positions

The combined administration of GH-releasing peptide-2 (GHRP-2), TRH and GnRH to men with prolonged critical illness evokes superior endocrine and metabolic effects compared to treatment with GHRP-2 alone