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Indeed, markers of systemic inflammation have been identified in FMS such as increased salivary and serum TNF-a , along with skin biopsies

A single mechanismeven HGF signallingmay be insufficient to address the complex cascade of tau pathology, inflammation, mitochondrial dysfunction, and vascular changes occurring in human disease

Initially studied in type 2 diabetes, it can help stimulate insulin release in the gut in response to food

The gastrointestinal tract is a protein-digesting machine

In fact, the impactof ROS and aldehydes seems to serve as key factor for these alterations, partially affirmed by the fact that intake of antioxidants prevents these EtOH-induced cellular alterations [20]