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In rodents, fragments of the GLP-1 metabolite may also have glucoregulatory effects, possibly mediated through hepatocytes [39], in line with previous observations of degradation of the GLP-1 metabolite [10, 40]
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formerly known as -glutamylcysteine synthetase)
As with allopurinol, it is reasonable whenever possible to add a preventative medication, such as colchicine, for at least the first six months after starting febuxostat to help avoid gout flares
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