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2 Methods Although numerous studies have investigated the role of ROS in cancer biology, the literature lacks a comprehensive structured review focusing specifically on in vitro experimental evidence supporting the pro-tumorigenic (tumor-promoting) roles of ROS in ovarian cancer
Examination of the GEO dataset of estrogen-stimulated MCF-7 cells revealed that the expression of SLC7A11 and SLC3A2 , components of the system x c responsible for cystine uptake, was upregulated following estrogen treatment (Fig
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