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Naive male mice subjected to intraperitoneal KYN treatment, the product of IDO, also produces depressive-like behavior in a dose-dependent manner [114], potentially because high levels of KYN would lead to a build-up of downstream metabolites like 3-HK

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It lies adjacent to key structures such as the pituitary gland, optic chiasm, and ventricular system, which circulates cerebrospinal fluid (CSF)

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