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Although the hypotensive effect of GLP-1 RAs seems to be manifested by BW losing, other mechanisms not related to BW might be implied by the mediation meta-analysis, which suggests an existence of BW-independent hypotensive effect of GLP-1 RA, along with the clinical evidence of weak or no correlations, and difference in time course between BP lowering and BW reducing effects

This multifaceted approach typically results in significant weight lossoften 515% of body weight depending on the specific agent and dose

According to Novo Nordisk and independent reporting, the approval was based on strong clinical trial results demonstrating meaningful weight loss outcomes

10.1016/j.neuroscience.2011.07.048 Neuroscience 20 BogenI

Research on semaglutide medications shows that weight loss often slows and begins to level off after about a year of treatment