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Preclinical studies in mice demonstrate significant reductions in fat mass and body weight without changes in food intake
The Critical Caveat All of the above is based largely on animal studies
Oral administration is not viablegastric acid and hepatic first-pass metabolism degrade peptide bonds within minutes, rendering the compounds inactive before reaching systemic circulation
Jaksa Vukojevic, Marija Milavic, Darko Perovic, Spomenko Ilic, Andrea Zemba Cilic, Natasa Duran, Sanja Strbe, Zoran Zoricic, Igor Filipcic, Petrana Brecic, Sven Seiverth, & Predrag Sikiric
The active species is the cation CHN at 159.21 g/mol, and it is supplied as the iodide salt, CHIN, molecular weight 286.11 g/mol, CAS 42464-96-0
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