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The result: pharmacological and physiological weight loss produced nearly identical muscle mass changes during immobilization

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adverse effects were broadly consistent with GI tolerability known for GLP-1/dual agonists, with higher discontinuation during rapid dose escalation

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For the assessment of the changes from baseline following GLP-1-based therapies in % FMD and IMT, mean differences with 95% confidence intervals (CI) were calculated between baseline samples and end-of-treatment samples for each study and then an overall effect size was generated