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Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study
doi:10.1038/npp.2015.166 Chayasirisobhon S
Some people lose weight with no nausea at all, and severe, persistent nausea should be discussed with your doctor
But, their TMAO AUC increased compared with placebo, representing a directionally opposite response to that observed in female participants of premenopausal age and male participants
