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For example, large-scale exosome production is challenging because exosomes derived from identical cell sources can still vary in content and bioactivity due to differences in growth conditions (e.g., temperature, media composition, and supplements), which affects yield and function [122]

Gluten sensitivity: As discussed previously, gluten consumption in those sensitive to gluten may trigger a histamine response by activating histamine receptors

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The patients metabolism will determine the response to this