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Retatrutide, a triple GIP/GLP-1/glucagon receptor agonist, achieved 24% body weight and 1.6% HbA1c reductions at 48 weeks in a phase II study of patients with obesity and T2DM
Once someone has been on an elevated dose for a few months, were going to taper them down over a month to a low dose and then ideally keep them there for like a month or two, he says
Tirzepatide is the active ingredient in FDA-approved products for type 2 diabetes and chronic weight management
The ideal candidate is someone who has a meaningful fat-loss goal, defined as 20 lbs or more to reduce, who is also concerned about how skin quality and connective tissue integrity will hold up through that process
Organic anion transporting polypeptide (OATP) transporter expression, localization and function in the human intestine
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