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We hypothesise that a few mechanisms may have contributed to the observed cardioprotective effects of GLP-1RAs in our study: (1) this class of glucose-lowering drugs induces weight loss, which has a positive impact and results in a better cardioprotective effect

Dosing and Administration Semaglutide is administered once weekly with starting dosing at 0.25 mg per week

The prevalence of grades 2 and 3 obesity (BMI 35 and 40 kg/m 2 , respectively) is about twice as high in women than in men (9, 10)

Within each zone, vary the exact spot slightly each cycle