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Interestingly, heterozygous KEAP1 mutations frequently occur in lung cancers (Singh et al., 2006
The 15 mg/kg dose was selected based on established efficacy and safety relative to known copper toxicity thresholds
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Selenium-enriched eggs predominantly provide selenium in organic forms, which exhibit superior absorption and biological efficacy compared with inorganic selenium sources (136)
Insulin resistance, as well as the conditions of hyperinsulinemia, hyperglycemia, and elevated free fatty acids, play a substantial role in causing injury to cardiomyocytes, deteriorating their functionality, and leading to myocardial lipotoxicity in individuals with diabetes [88]
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