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Pathogenic variants in the SLC12A3 gene which encodes the Na + /Cl cotransporter identified as NCC (also identified as NCCT) are the cause of Gitelman syndrome
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Despite widespread anecdotal claimssome describing these agents in near-miraculous termsthe extent to which peptides deliver meaningful clinical benefit remains uncertain
They are more prone to developing new allergies, including contact allergies to topical agents
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