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There isnt any scientific evidence that taking berberine after a meal wont be effectivebut taking it before or with a meal is generally recommended because of the way its metabolized, and it may help lessen GI side effects

[PMID: 17878454] PubMed record related to this compound for laboratory literature review

J Am Coll Cardiol 57(16):16411649 Schultheiss HP, Fairweather D, Caforio ALP, Escher F, Hershberger RE, Lipshultz SE, Liu PP, Matsumori A, Mazzanti A, McMurray J, Priori SG (2019) Dilated cardiomyopathy

Tea polyphenols in promotion of human health