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These medications mimic a naturally occurring hormone (GLP-1) that regulates appetite and blood sugar

Tirzepatide's common side effects are nausea, vomiting and diarrhea, typically mild to moderate and dose-dependent, with a personal history of medullary thyroid cancer or MEN2 syndrome as contraindications

doi: 10.1186/s13059-017-1273-4 241 OlejniczakM.Kotowska-ZimmerA.KrzyzosiakW

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Persistent constipation should be reviewed, especially if it affects eating, sleep, work, or comfort