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Mild to moderate diarrhea is a predictable side effect that typically doesn't require discontinuation

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Average weight loss with Contrave is approximately 5-8% of body weight, lower than tirzepatide but meaningful for people whose weight gain is driven by emotional eating, food addiction, or reward-seeking behavior patterns

Peer review discussions suggest potential relevance for endothelial and microvascular dysfunction

Hydration Guidelines : Aim for adequate daily fluid intake based on your individual needs, which vary depending on body size, activity level, climate, and health conditions