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Most of what is marketed for the brain belongs to the first camp, a smaller and more demanding set belongs to the second, and a few interventions fall between them

50 However, two phase 3 trials of selonsertib (an ASK-1 inhibitor) were terminated early due to a lack of efficacy in MASH adults with stage 3 (NCT03053050) and stage 4 (NCT03053063) fibrosis