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189 Further, ME1 treated with the inhibitor (piperazine-1-pyrrolidine-2,5-dione) has little effect on normal rat intestinal epithelial cells but strongly suppresses human CRC cell growth by targeting ME1 NADP + -binding site and reducing the NADPH level

Foods high in dietary protein such as beef , fish , and poultry also contain significant amounts of sulfur

Acknowledgements We thank Kevin Vogt for helpful assistance in the preparation of this manuscript

For the enzyme activation, the YxxL sequences must be spaced apart to engage both of the SH2 domains of Syk family kinase (Figure 5)

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