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Ozempic compared to Trulicity led to: lower blood sugars based on HbA1c by about 0.3% (-1.4% vs -1.1%)

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In June 2025, MBX Biosciences In announced it received preliminary feedback from the FDA on its planned Type B pre-IND meeting, supporting the advancement of its EL-22 program in combination with GLP-1 receptor agonists toward a Phase 2 clinical trial

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Again, this is where estradiol also exerts a number of direct effects on appetite, thus raising the possibility of estradiol-insulin interactions to alter food intake