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[5] Several biological mechanisms have been proposed in preclinical research that suggest plausible links between GLP-1 signalling and brain health: Neuroprotection : In laboratory and animal studies, GLP-1 receptor activation may protect neurons from oxidative stress and inflammation, both of which contribute to neurodegeneration [5] Neurogenesis : Animal studies suggest GLP-1 may promote the growth of new neurons in the hippocampus, a region essential for memory Reduction of amyloid plaques : Preclinical research indicates potential effects on beta-amyloid accumulation, a hallmark of Alzheimer's disease [5] Anti-inflammatory effects : Chronic neuroinflammation is implicated in various forms of dementia The connection between metabolic health and cognitive function provides additional rationale for investigating GLP-1 agents in dementia

We recommend patients reduce their portion size and stop eating once they start feeling full when starting the medication

Place the medication in the passenger cabin, not the trunk

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Starting January 2026, you may have an alternative to the injection: CV Risk Reduction: Alternative Coverage Pathway Wegovy is the only obesity medication FDA-approved to reduce cardiovascular risk (March 2024)