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In an analysis of 11 studies, alpha-lipoic acid significantly lowered levels of the inflammatory marker C-reactive protein (CRP) in adults with high levels of CRP (29)
In DR, high glucose inhibits Nrf2 activity by activating protein kinase C (PKC) and accumulating advanced glycation end products (AGEs), reducing retinal cell GSH/GPx4 levels, impairing iron export, inducing free iron and LPO accumulation, and activating ferroptosis in Mller, ARPE and endothelial cells, exacerbating vascular leakage (134136)
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10.1186/s13072-019-0314-5 94 WangS.ZhangR.WangD
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