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Cultural Awareness and Marketing: High-profile media attention, celebrity endorsement, and powerful direct-to-consumer (DTC) marketing have brought GLP-1s into the public consciousness

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Inform patients receiving semaglutide treatment that gastrointestinal side effects may pose a risk of dehydration, and be careful to avoid fluid shortages

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Different types of antibodies facilitated crystallization of GLP-1R and GCGR into varied ECD orientations, whereas the structural differences in the TMD extracellular regions, including the stalk of helix I, is potentially due to sequence diversity between the two receptors