doi: 10.1080/26410397.2022.2044198
(Depending on your starting weight, this can equal 30+ pounds.) 1
Panel b : Data are presented as arithmetic means for lipase
In other words, it can break down through photolysis (destruction by light) unless you store it properly

You should consider speaking to your GP if: You have been consistently following a calorie deficit for four to six weeks or more with no measurable change in weight or body measurements You are experiencing unexplained fatigue, cold intolerance, hair loss, or constipation , which may suggest an underactive thyroid (hypothyroidism) see NICE CKS: Hypothyroidism You have irregular menstrual cycles , excess facial or body hair, or acne, which may indicate PCOS see NICE CKS: Polycystic ovary syndrome You have a personal or family history of metabolic conditions, type 2 diabetes, or cardiovascular disease You are considering a very low-calorie diet (below 800 kcal per day), which should only be undertaken under medical supervision see NHS guidance on very low-calorie diets You notice unexplained weight gain despite a genuine deficit You experience unintentional weight loss , persistent changes in bowel habit, rectal bleeding, unexplained fevers or night sweats, or symptoms of high blood sugar (such as increased thirst, frequent urination, or fatigue) these warrant prompt assessment
