On the other hand, PI3K inhibition may abrogate the suppression of GSK3 and FOXO by Akt thereby promoting IGF-IR expression [124, 125]
To overcome the barriers and to improve the adherence, oral GLP-1 RAs were needed, but oral protein-based drug absorption is limited because of degradation in the stomach due to low pH, proteolytic enzyme activity, and limited permeability across the gastrointestinal (GI) epithelium
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Funding This work was supported by the Hebei Provincial Central leading Local Science and Technology Development funds Project (206Z7702G)
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