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Interestingly, previous transcriptional analysis uncovered that AITC treatment affected the expression profile of certain genes involved in the regulation of cell cycle 23 , indicating the phytochemical-induced growth inhibition might be an indirect consequence of cell cycle misregulation due to GSH depletion

Mechanistically, its effects cluster around vascular remodeling, nitric-oxide (NO) signaling, extracellular-matrix repair, and inflammation control

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For those lactating and pregnantNot recommended for use

Glutathione S-transferase alpha 4 induction by activator protein 1 in colorectal cancer