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Subjects with a history of endocrine disorders were excluded, and other exclusion criteria were standard for a clinical pharmacology study in healthy subjects

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Additionally, some IBS patientsparticularly those with IBS-C (constipation-predominant)may experience worsening of slow transit and constipation when starting GLP-1 medications, as these drugs naturally slow gastric emptying

AOXs have shown promise in the management of PCOS, endometriosis, poor ovarian reserve and unexplained infertility

The Discovery and Development of Human GLP-1 Product details Product details Edition: 1 Latest edition Published: March 3, 2026 Language: English About the author About the author JH Jens Juul Holst Jens Juul Holst is Professor of Medical Physiology at the Department of Biomedical Sciences, University of Copenhagen