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Podocytes also present an insulin-dependent alternative pathway, the cyclic guanosine monophosphate(cGMP)-dependent protein kinase G (PKG), from which the PKG isoform I-alpha levels are increased in glomeruli of the hyperinsulinemic Zucker rats ( An important player in podocytes physiology is the protein nephrin, a podocyte-specific protein, which is responsible for the maintenance of the integrity of the filtration barrier

C., Ibi, A., Wood, S., Hardy, M., Gahler, R

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J.SilvaC.et al (2002)