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Future Therapeutic Directions The repeated failure of amyloid-targeted and metabolic therapies underscores the need to move beyond the amyloid cascade hypothesis and embrace alternative molecular mechanisms

95% CI 0.310.84)

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As such, the association with efficacy may be the result of enhanced trafficking of the protein within the cell that ultimately modulates the cell surface abundance of the receptor, rather than the result of alterations in the receptor protein structure that may influence ligand affinity

1.5-3.0 g/day for one year) in individuals with diabetic peripheral neuropathy (3, 88)