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Radtke et al., 2012)
Note additionally that the three methionine residues in the sequence, two of them in the N-terminal extension, make dilute standing solution vulnerable to oxidation, and that freeze-thaw cycling promotes aggregation in disulfide-bonded proteins more readily than in short peptides
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Molinar VE, Taylor SC, Pandya AG
Epidemiological studies suggest the relative risks for these disorders is increased by approximately 25% following intrauterine exposure to acetaminophen, but the molecular mechanism remains unknown (Buhrer 2021)
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