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Much more research is needed to uncover the potential benefits, as well as risks, of these medications
In 2019, Crizanlizumab, a P-selectin inhibitor, was approved by the FDA for the prevention of vaso-occlusive crises in patients with sickle cell disease (Figure 1)
CagriSema's 20.4% mean weight loss on ITT analysis (22.7% on-treatment) means: ~60% of participants lost 20% body weight
Diabetologia 59:13721375 Liang Y, Osborne MC, Monia BP et al (2004) Reduction in glucagon receptor expression by an antisense oligonucleotide ameliorates diabetic syndrome in db / db mice
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