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Allocation was generated centrally using computerised randomisation

-Ketoglutarate (-KG), a TCA cycle intermediate, serves as an essential cofactor for TET and JmjC demethylases, facilitating DNA and histone demethylation [251]

Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver

Starting at the lowest dose and increasing slowly over months, rather than rushing to the target dose, dramatically reduces gastrointestinal side effects and improves long-term tolerability

There are no scheduled follow-ups, no monthly questionnaires, and no required check-ins, which works for patients who want to stay on a stable dose but may bother anyone who wants closer monitoring